Simulations and power calculations
How many subjects are needed in your study? We are experts in power calculations, even for complex scenarios. In our experience, many clinical trials are too complex to be handled by the software available. When power is calculated for a simplified scenario, the true sample size may be underestimated or overestimated.
An alternative approach is to use simulation-based sample calculations. A simulated calculation can reflect the accurate analysis of complex scenarios without the need to simplify. Another advantage with simulation-based calculations is that we are able to avoid some of the model assumptions which the analytical calculations require.